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Eliquis® (apixaban)

Risk Minimisation Information for Healthcare Professionals

Therapeutic indication: Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults1,2

Dosing recommendations

The recommended dose of apixaban for the treatment of acute DVT and treatment of PE is 10 mg taken orally twice daily for the first 7 days followed by 5 mg taken orally twice daily with water, with or without food.

As per available medical guidelines, short duration of treatment (at least 3 months) should be based on major transient/reversible risk factors (e.g. recent surgery, trauma, immobilisation).

The recommended dose of apixaban for the prevention of recurrent DVT and PE is 2.5 mg taken orally twice daily with water, with or without food.

When prevention of recurrent DVT and PE is indicated, the 2.5 mg twice daily dose should be initiated following completion of 6 months of treatment with apixaban 5 mg twice daily or with another anticoagulant, as indicated in Figure 3.

Figure 3

Treatment of acute DVT or PE (at least 3 months)

Day 1–7

Dosing Schedule
apixaban 2.5 mg Morning
apixaban 5 mg eliquis Night
Daily Dose
10 mg twice daily

eliquis apixaban 5 mg

apixaban 5 mg

eliquis apixaban 5 mg

apixaban 5 mg

eliquis apixaban 5 mg

apixaban 5 mg

eliquis apixaban 5 mg

apixaban 5 mg

20 mg

Day 8 onwards

Dosing Schedule
apixaban 2.5 mg Morning
apixaban 5 mg eliquis Night
Daily Dose
5 mg twice daily

eliquis apixaban 5 mg

apixaban 5 mg

eliquis apixaban 5 mg

apixaban 5 mg

10 mg
Prevention of recurrent DVT and/or PE following completion of 6 months anticoagulation treatment

Dosing Schedule
apixaban 2.5 mg Morning
apixaban 5 mg eliquis Night
Daily Dose
2.5 mg twice daily

eliquis 2.5 mg dosage

apixaban 2.5 mg

eliquis 2.5 mg dosage

apixaban 2.5 mg

5 mg

The duration of overall therapy should be individualised after careful assessment of the treatment benefit against the risk for bleeding.

For patients who are unable to swallow whole tablets, apixaban tablets may be crushed and suspended in water, or 5% glucose in water (G5W), or apple juice or mixed with apple puree and immediately administered orally. Alternatively, apixaban tablets may be crushed and suspended in 60 mL of water or G5W and immediately delivered through a nasogastric tube. Crushed apixaban tablets are stable in water, G5W, apple juice, and apple puree for up to 4 hours.

Missed dose

If a dose is missed, the patient should take apixaban immediately and then continue with twice daily intake as before.

Click below for information on use in specific patient populations.

Renal impairment  
Dialysis Not recommended
Renal failure
(CrCl <15 ml/min)
Not recommended
Severe renal impairment (CrCl 15–29 ml/min) Use with caution
Mild (CrCl 51–80 ml/min) or moderate (CrCl 30–50 ml/min) renal impairment No dose adjustment required

This Prescriber Guide is not a substitute for the apixaban Summary of Product Characteristics (SmPC). Please consult the SmPC for full prescribing information.