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Eliquis® (apixaban)
Risk Minimisation Information for Healthcare Professionals
Risk Minimisation Information for Healthcare Professionals
The recommended dose of apixaban is 2.5 mg taken orally twice daily with water, with or without food. The initial dose should be taken 12 to 24 hours after surgery.
Physicians may consider the potential benefits of earlier anticoagulation for VTE prophylaxis as well as the risks of post-surgical bleeding in deciding on the time of administration within this time window.
In patients undergoing hip replacement surgery, the recommended duration of
treatment is 32 to 38 days.
In patients undergoing knee replacement surgery, the recommended duration of
treatment is 10 to 14 days.
For patients who are unable to swallow whole tablets, apixaban tablets may be crushed and suspended in water, or 5% glucose in water (G5W), or apple juice or mixed with apple puree and immediately administered orally. Alternatively, apixaban tablets may be crushed and suspended in
If a dose is missed, the patient should take apixaban immediately and then continue with twice daily intake as before.
Click below for information on use in specific patient populations.
| Renal impairment | |
| Dialysis | Not recommended |
| Renal failure (CrCl <15 ml/min) |
Not recommended |
| Severe renal impairment (CrCl 15–29 ml/min) | Use with caution |
| Mild (CrCl 51–80 ml/min) or moderate |
No dose adjustment required |
| Hepatic impairment | |
| Hepatic disease associated with coagulopathy and clinically relevant bleeding risk | Contraindicated |
| Severe hepatic impairment | Not recommended |
| Mild or moderate hepatic impairment (Child Pugh A or B) |
Use with caution No dose adjustment required |
Prior to initiating apixaban, liver function testing should be performed. Patients with elevated liver enzymes ALT/AST
This Prescriber Guide is not a substitute for the apixaban Summary of Product Characteristics (SmPC). Please consult the SmPC for full prescribing information.